Structure and physicochemical properties of water, for example their dipole moment, results in formation of cluster of water molecules bound together by hydrogen bounding. Formation of water clusters has been investigated in vitro and there are some indications that formation of water clusters can influence aqueous solubility of drugs, especially lipophilic drugs that have only limited solubility in water. Also, there are some indications that water clusters can increase physical stability of molecular aggregates and that formation of such aggregates interferes with high throughput screening for new chemical entities. Furthermore, in vitro studies have indicated that layers of stagnant water molecules could be water clusters. Carbohydrates and glycoproteins at membrane surfaces can perhaps enhance formation of such clusters. Little or no information is available on formation of water clusters in vivo.

The purpose of this project is to investigate the influence of cluster formation on the aqueous solubility of drugs and their ability to permeate biological membranes.

Applicants must have finished MS degree(or equivalent) in pharmacy, chemistry, biochemistry, physicalchemistry or in related subjects. This is a three year fellowship, about 35,000- EUR per year. For further information on the faculty of Pharmacy and the research group please go to the web-site: www.hi.is/~thorstlo

Closing date: 01-Sep-07

Contact Person:
Thorsteinn Loftsson
Tel: +354 525 4464
Fax: +354 525 4071
E-Mail: thorstlo@hi.is