USA: Molecular Biologist for Studies of Human Autism and Epilepsy Disease Genes in Transgenic Mice
Molecular Biologist for Studies of Human Autism and Epilepsy Disease Genes in Transgenic Mice, USA
Individual needed with strong molecular biology skills to recreate genetic forms of human autism and epilepsy using BAC recombineering, ES cell homologous recombination, and mouse transgenics. Target the disease gene to specific cell-types using Cre recombinase/loxP technologies (Anderson et al. 2005 PNAS). Use recombineered epitope tags to isolate and characterize the native protein complexes associated with these disease gene proteins (BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods. 2008 5:409-15). An MD and/or PhD degree and extensive prior experience with molecular biology and proteomics techniques are required.
Contact: Matthew P. Anderson M.D., Ph.D. (mpanders[ at ]bidmc.harvard.edu)
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