A Career Development position is available for 3 years in the lab of Dr. Tim Humphrey (Cell Cycle Group) at the above Unit (www.ragsu.har.mrc.ac.uk/).  

Most human cancers are genetically unstable and exhibit gross chromosomal rearrangements including deletions, duplications, truncations and translocations. Recent evidence suggests that DNA double-strand breaks (DSBs), arising from exogenous or endogenous events, are early contributors to tumorigenesis. Understanding how DSBs may induce chromosomal rearrangements and how they are normally suppressed is central to cancer research. The applicant will examine these issues using powerful technology developed in fission yeast, in which the cellular responses to DNA damage are highly conserved. Potential tumour suppressor genes identified will be studied further in mammalian systems. Our research establishment offers a wide range of opportunities in a dynamic, multi-disciplinary environment. There are excellent research facilities, working conditions, and formal links with Oxford University. Those who have a strong background in yeast genetics and/or molecular biology are encouraged to apply.

Career Development positions (i.e. fixed-term post doctoral appointments) are classified by the MRC as training posts.  If you are appointed to such a post, you will benefit from the MRC Post Doctoral Development Programme.  Attendance on certain courses in this programme is mandatory. Additional benefits include 30 days annual leave and pension scheme. Salary from £24,501.

Informal enquiries welcome to Tim Humphrey (T.Humphrey@har.mrc.ac.uk).
For a job information sheet/application form contact the Personnel Office, (personnel@har.mrc.ac.uk) Medical Research Council, Harwell, Didcot, Oxon, OX11 0RD. Tel 01235 841069

Closing date 24th June 2005

Source: Post-Doctoral Position available in DNA Breaks, Chromosome Stability and Cancer